Table 3.
Comparisons between BBL-gB-CAR-T cell-treated relative to the control nontreated humanized mice infected with human cytomegalovirus/Gaussia luciferase
| 1 Week | CTR |
NR |
R |
p |
||
|---|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | CTR × NR | CTR × R | ||
| OI: Full abdomen | Pixels/s | 2.92E+08 (2.26E+07) | 3.29E+08 (1.91E+07) | 2.34E+08 (1.73E+07) | ns | ** |
| OI: Liver | 1.25E+08 (2.04E+07) | 1.61E+08 (2.47E+07) | 9.46E+07 (7.76E+06) | * | * | |
| OI: Salivary glands | 3.54E+07 (3.09E+06) | 4.15E+07 (2.90E+06) | 3.16E+07 (2.10E+06) | * | ns | |
| RT-qPCR: Liver | Copies/μg | 5.04E+02 (8.22E+02) | 6.93E+02 (4.89E+02) | 1.51E+03 (2.35E+03) | ns | ns |
Optical imaging analyses quantified in regions of interest on the full abdomen, the liver region, and the salivary gland regions, as well as RT-qPCR detection of HCMV-copies in the liver. Shown are results for individuals analyzed 1 week after administration of the T cells. The control group was not treated with CAR-T cells (CTR); the CAR-T cell-treated group was divided into responder (R) and nonresponder individuals (NR). Statistical significance was determined by one-way ANOVA and Dunnett's post hoc tests comparing with the control group.
*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.
OI, optical imaging; RT-qPCR, quantitative real-time PCR.