Table 2.
Other viral vectors mediating glutamic acid decarboxylase expression for analgesia
| Vector Type | Gene | Animal Model | Routes of Vector Delivery | Results | References |
|---|---|---|---|---|---|
| AV | GAD67 | Mice SNT | L4 spinal nerve | Reduced mechanical allodynia; preventing SNT-induced neuropathic pain, suppressed the elevation of Cav3.2 mRNA in the DRG | 63 |
| AV | GAD65 | Rat orofacial formalin test | Trigeminal ganglion | Decrease pain behavior, which was blocked by bicuculline | 71 |
| AAV | GAD65 | Rat tibial and sural nerve ligation | Sciatic nerve injection | Reduced mechanical hyperalgesia and allodynia, and c-fos activation | 66 |
| AAV | GAD65 | Rat tibial and sural nerve transected | L4/5 DRG | Reduced mechanical hyperalgesia and allodynia | 67 |
| HFV | GAD67 | Rat SCI | Hind paws | Reversed mechanical allodynia and thermal hyperalgesia | 68 |
AAV, adeno-associated virus; AV, adenoviral vector; HFV, human foamy virus; SCI, spinal cord injury; SNT, spinal nerve transection.