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Comparison of expressed MAD7 and Cas9 activity in human HCT116 cells
| Gene target | Guide RNA | MAD7 indels (%) | Cas9 indels (%) |
|---|---|---|---|
| PPIBa | 1 | 20 ± 0 | 26 ± 2 |
| 2 | 20 ± 1 | ||
| 3 | 7 ± 1 | ||
| DNMT3Ba | 1 | 8 ± 1 | 23 ± 2 |
| 2 | 7 ± 2 | ||
| 3 | 14 ± 3 | ||
| NF1b | 1 | 15 ± 2 | 20 ± 2 |
| STAG2b | 1 | 23 ± 2 | 28 ± 2 |
| ALK2b | 1 | 4 ± 0 | 14 ± 1 |
| CACNA1Dc | 1 | 14 ± 2 | 29 ± 1 |
| PPP1R12Cc | 1 | 6 ± 1 | 15 ± 1 |
Non-overlapping targets.
Fully overlapping targets.
Overlapping seed.
