Skip to main content
. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Trends Cancer. 2020 Mar 13;6(5):407–418. doi: 10.1016/j.trecan.2020.02.006

Figure 2: Comparison of Zebrafish and Mouse Models of Pediatric Cancer.

Figure 2:

Zebrafish and mouse models of pediatric cancer have complementary attributes for identifying new mechanisms driving childhood tumors. Both model systems have conserved developmental and oncogenic pathways, can be utilized for PDXs, and have genome-editing technologies available. Zebrafish have unique advantages in scalability, cost and imaging. In contrast, mice have conserved physiological features (body temperature and organ systems) and more accurate drug delivery, dosing and metabolism.