Figure 8:

(Left) 50%-responder rate (RR50) endpoints from one randomly simulated trial for placebo and drug arm, p-value calculated using Fisher exact test. (Right) Median percentage change (MPC) endpoints from one simulated trial for placebo and drug arm, p-value calculated using Wilcoxon Signed Rank Test. This graph shows the RR50 and MPC from one trial of the RCT simulations which are both within 1 standard deviation of the estimated RR50 and estimated MPC of 5000 simulated trials, i.e. typical of the larger simulated trial set (Figure 5).