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. 2020 May 14;9:217. Originally published 2020 Mar 30. [Version 2] doi: 10.12688/f1000research.22689.2

Figure 1. Ephrin-A1-deficient hosts have reduced metastasis and tumor recurrence but no difference in primary tumor growth.

Figure 1.

( A) 4T1 primary tumor growth curves in age-matched female Efna1 +/+ (WT) and Efna1 -/- (KO) mice and resulting tumor weights at day 21 post-implantation. ( B) Schematic diagram showing experimental procedure for evaluating spontaneous metastases. ( C) 4T1 primary tumor growth curves in WT and KO mice and resultant tumor weights at time of surgical resection on day 14. ( D) 4T1 primary tumor growth curves in WT, heterozygous (+/-) and KO littermates and resultant tumor weights at time of surgical resection on day 14. ( E) Blinded quantification of visible lung metastases and lung weights from WT and KO mice at experimental endpoint on day 32. ( F) Weights of recurrent 4T1 tumor at primary site 18 days after surgical resection. Data shown are averages ± SD with each data point representing an individual mouse ( n=9–12 mice per group). * p<0.05, ** p<0.01 (unpaired Mann-Whitney U-test).