Table 2.
Enriched Transcription Factors with VDR ChIP-seq Peaks from RWPE1 Cells.
| TF Related Gene | TF Interaction Network | Peak signal1 | DR3 in Peak | VD effect in RWPE1 array | Peak in Multiple Cell Types |
|---|---|---|---|---|---|
| CREB1 | Y | VD | - | 48 h, − | N |
| EPAS1 | Y | VD | - | 24 h, + | N |
| FOS | Y | VD | + | all, + | Y |
| GLI3 | Y | VD | + | NS | Y |
| HIF1A | Y | VD | + | 6, 48 h, + | Y |
| KLF4 | Y | VD | + | 6 h, + | Y |
| KLF9 | Y | VD | + | NS | Y |
| NFKBIA | RELB | VD | + | 6, 24 h, + | Y |
| RARA | Y | VD | + | NS | Y |
| SMAD2 | Y | VD | + | NS | N |
| SRF | Y | VD | - | 48 h, + | N |
| TP73 | Y | VD | - | 46 h, − | N |
| DEC1 | Y | C | + | NS | N |
| ESR1 | Y | C | + | NS | N |
| ETS1 | Y | C | - | 6, 48 h, − | Y |
| GLI2 | Y | C | - | 48 h, − | N |
| MYC | Y | C | - | 6 h, − | N |
| SMAD3 | Y | C | - | 24 h, − | N |
| AHR | Y | B | + | 6 h, + | N |
| FOXO1 | Y | B | + | 6, 48 h, + | Y |
| RBPJ (CBF1) | Y | B | + | 48 h, − | Y |
| TBP | Y | B | + | 6 h, − | Y |
1
C = peak in ethanol treated control; B = peak in both groups; VD = peak in 1,25(OH)2D-treated group