Table I.
Summary of reported COVID-19 cases with cutaneous manifestations between January 1, 2020, and April 19, 2020
Authors∗ | No. | Age, y and sex | Cutaneous manifestations | Extracutaneous manifestations | Laboratory-confirmed COVID-19 case | Associated with disease severity | Skin biopsy | Progression | Article link |
---|---|---|---|---|---|---|---|---|---|
Reported cases with skin manifestations that indicate viral exanthems | |||||||||
Guan et al | 2 of 1099 | NA | NA | NA | Yes | Yes | No | NA | https://doi.org/10.1056/NEJMoa2002032 |
Joob and Wiwanitkit | 1 | NA | Skin rash with petechiae | Fever, thrombocytopenia, respiratory symptoms | Yes | NA | No | NA | https://doi.org/10.1016/j.jaad.2020.03.036 |
Recalcati | 18 of 88 | NA | Erythematous rash (n = 14), widespread urticaria (n = 3), chickenpox-like vesicles (n = 1) | NA | Yes | No | No | NA | https://doi.org/10.1111/jdv.16387 |
Hunt and Koziatek | 1 | 20, M | Diffuse nonpruritic erythematous morbilliform rash on trunk and extremities | Fever, multifocal pneumonia with decreased oxygen saturation | Yes | Yes | No | NA | https://doi.org/10.5811/cpcem.2020.3.47349 |
Mahé et al | 1 | 64, F | Erythematous rash on both antecubital fossa, trunk, and axillary folds resembling symmetric drug-related intertriginous and flexural exanthem | Fever, cough, asthenia, bilateral pneumonia | Yes | No | No | Improved within 5 days | https://doi.org/10.1111/jdv.16471 |
Jimenez-Cauhe et al | 1 | 84, F | Mild pruriginous erythematous-purpuric, coalescing macules on the periaxillary area | Bilateral pneumonia | Yes | NA | No | NA | https://doi.org/10.1016/j.jaad.2020.04.016 |
Marzano et al | 22 | 8-90; 16M and 6F | Diffuse/scattered papulovesicular lesions on trunk (n = 22) and extremities (n = 4), mild itch (n = 9), pain (n = 2), burning (n = 3) | Fever, cough, headache, weakness, coryza, dyspnea, hyposmia, hypogeusia, pharyngodynia, diarrhea, myalgia | Yes | No | Yes (n = 7) | 4-15 days | https://doi.org/10.1016/j.jaad.2020.04.044 |
Lu et al | 1 | NA | Urticaria | Bilateral pneumonia with minimal symptom | No | No | No | NA | https://doi.org/10.1002/jmv.25776 |
Henry et al | 1 | 27, F | Generalized urticaria on face and extremities | Odynophagia, arthralgia, chills, fever, chest pain | Yes | No | No | NA | https://doi.org/10.1111/jdv.16472 |
Fernandez-Nieto et al | 1 | 32, F | Urticaria | NA | Yes | No | Yes | Improved within 5 days | https://doi.org/10.1111/jdv.16470 |
Hoehl et al | 1 of 2 | NA | Faint rash | Minimal pharyngitis | Yes | No | No | NA | https://doi.org/10.1056/NEJMc2001899 |
Reported cases with vasculopathy-related skin manifestations | |||||||||
Zhang et al | 7 | 49-71; 4 M and 3 F | Finger/toe cyanosis, skin bullae, and dry gangrene | Fever, cough, dyspnea, diarrhea | Yes | Yes | No | NA | https://doi.org/10.3760/cma.j.issn.0253-2727.2020.0006 |
Mazzotta and Troccoli | 1 | 13, M | Erythematous-violaceous rounded lesions on toes with 1-cm diameter, tense blister, blackish crusts at 7 days later | Low-grade fever, muscle pain, headache | No | No | No | Regressed in 2 weeks | http://sectcv.es/wp-content/uploads/2020/04/acroischemia-ENG.pdf |
Manalo et al | 2 | 67, M | Transient nonpruritic blanching unilateral livedoid patch on right thigh | Low-grade fever, nasal congestion, post-nasal drip, cough, hematuria | Yes | Yes | No | Resolved within 19 hours | https://doi.org/10.1016/j.jaad.2020.04.018 |
47, F | Unilateral transient asymptomatic rash on right leg resembling livedo reticularis | Low-grade fever, mild headache, sinus pressure, anosmia | Yes | No | No | Resolved within 20 minutes | |||
Ma et al | 1 of 3 | 69, M | Dry gangrene on right index finger | Fever, bilateral pneumonia, antiphospholipid syndrome with cerebral infarcts | Yes | Yes | No | NA | https://doi.org/10.1016/j.clim.2020.108408 |
Zhang et al | 1 of 3 | 69, M | Ischemia on both lower limbs and digits of the left hand | Fever, bilateral pneumonia, diarrhea, headache, multiple cerebral infarcts, positive antiphospholipid antibodies | Yes | Yes | No | NA | https://doi.org/10.1056/NEJMc2007575 |
Alramthan and Aldaraji | 2 | 27 and 35; 2 F | Red-to-purple papules on the dorsal aspects of fingers (n = 2), diffused erythema in the subungual area of the right thumb (n = 1), clinical features resembling chilblains | None | Yes | No | No | NA | https://doi.org/10.1111/ced.14243 |
Estebanez et al | 1 | 28, F | Confluent erythematous-yellowish papules on both heels, later developed into pruritic erythematous plaques resembling urticarial vasculitis | Dry cough, nasal congestion, fatigue, myalgia, arthralgia, diarrhea, ageusia, anosmia | Yes | No | No | NA | https://doi.org/10.1111/jdv.16474 |
F, Female; M, male; NA, not available.
References supporting this table are available from the corresponding author upon request.