Table 4.
The value of blood routine parameters in diagnosis of severe COVID-19 on admission.
| Blood routine parameters | AUC (95%CI) | Sensitivity (95%CI) | Specificity (95%CI) | PPV (95%CI) | NPV (95%CI) | P value |
|---|---|---|---|---|---|---|
| Leucocytes > 7.1 (×109 per L) |
0.709 (0.574–0.844) |
55.56 (35.3–74.5) |
93.26 85.9–97.5) |
71.4 (47.8–88.7) |
87.4 (78.9–93.3) |
<0.003 |
| Neutrophils > 5.7 (×109 per L) |
0.774 (0.653–0.896) |
51.85 (31.9–71.3) |
98.88 (93.9–100.0) |
93.3 (68.1–99.8) |
87.1 (79.0–93.0) |
<0.001 |
| Lymphocytes ≤ 0.86 (×109 per L) |
0.856 (0.777–0.936) |
81.48 (61.9–93.7) |
76.40 (66.2–84.8) |
51.2 (35.5–66.7) |
93.2 (84.7–97.7) |
<0.001 |
| Eosinophils ≤ 0 (×109 per L) |
0.763 (0.641–0.886) |
48.15 (28.7–68.1) |
98.88 (93.9–100.0) |
92.9 (66.1–99.8) |
86.3 (78.0–92.3) |
<0.001 |
| MLR > 0.43 | 0.862 (0.778–0.947) |
85.19 (28.7–68.1) |
76.40 (66.2–84.8) |
52.3 (36.7–67.5) |
94.4 (86.4–68.5) |
<0.001 |
| NLR > 4.5 | 0.888 (0.812–0.963) |
74.07 53.7–88.9) |
89.89 81.7–95.3) |
69.0 (48.8–85.0) |
92.0 (84.1–96.7) |
<0.001 |
| PLR > 226.67 | 0.746 (0.637–0.854) |
59.26 38.8–77.6) |
80.90 71.2–88.5) |
48.5 (30.8–66.5) |
86.7 (77.5–93.2) |
<0.001 |
| MLR + NLR > 0.1214 | 0.925 (0.867–0.983) |
96.30 81.0–99.9) |
76.40 66.2–84.8) |
55.3 (40.1–69.8) |
98.6 (92.2–100) |
<0.001 |
AUC: area under the curve; CI: confidence intervals PPV: positive predictive value; NPV: negative predictive value; NLR: Neutrophils-to-lymphocytes ratio; MLR: Monocyte-to- lymphocytes ratio; PLR: Platelet-to- lymphocytes ratio; MLR + NLR: the integration parameters of MLR and NLR; COVID-19 = coronavirus disease 2019.