Baseline BPF vs. EDSS score at baseline and 5-year follow-up
Brain parenchymal fraction (BPF) at baseline vs. Expanded Disability Status Scale (EDSS) score at baseline and at 5-year follow-up from the Brigham and Women’s Hospital (BWH) (top) and the University of California, San Francisco (UCSF) (bottom) cohorts. Scatter plots with regression slopes illustrate the relationship between whole brain atrophy and EDSS score at baseline (BWH: Pearson r = −0.174, p=0.084, UCSF: r = −0.371, p<0.001), and at 5-year follow-up (BWH: Pearson r = −0.072, p=0.479, UCSF: r = −0.366, p<0.001). The correlation coefficients were different between the two cohorts at the 5-year time point (p<0.05). See also Table 2.