Table 4.

Whole brain volume measurement at the UCSF site: comparison of two methods

	BPF	BPV
Disease duration	−0.331 (−0.495, −0.144) p=0.001**	−0.332 (−0.496, −0.145) p=0.001**
EDSS at baseline	−0.371 (−0.528, −0.188) p<0.001***	−0.370 (−0.528, −0.187) p<0.001***
EDSS at 5y	−0.366 (−0.525, −0.183) p<0.001***	−0.362 (−0.522, −0.178) p<0.001***
EDSS 5y change	−0.037 (−0.232, 0.160) p=0.711	−0.033 (−0.228, 0.165) p=0.745
T2LV	−0.227 (−0.406, −0.032) p=0.023*	−0.231 (−0.409, −0.037) p=0.021*
Age	−0.523 (−0.653, −0.364) p<0.001***	−0.526 (−0.655, −0.367) p<0.001***

Key: Pearson correlations between the clinical/demographic variable in the first column and whole brain volume, with 95% confidence intervals. UCSF = University of California, San Francisco; BPF = brain parenchymal fraction; BPV=normalized brain parenchymal volume; EDSS = Expanded Disability Status Scale score; T2LV = global cerebral T2 hyperintense lesion volume (the cube root-transformed T2LV was used);

^*p<0.05;

^**p<0.01;

^***p<0.001.