Table 1.
Baseline Characteristics of the Propensity Score-Matched Patient Population (2013 to 2018)
| Characteristic | Fresh Grafts | Cryopreserved Grafts | P Value |
|---|---|---|---|
| Number of patients | 1080 | 274 | |
| Age at transplantation, yr, median (range) | 52 (19-80) | 55 (22-75) | .33 |
| Male sex, n (%) | 620 (57.4) | 163 (59.5) | .53 |
| Karnofsky performance score ≥90, n (%) | 536 (49.6) | 137 (50) | .71 |
| Not reported, n (%) | 13 (1.2) | 5 (1.8) | |
| Race, n (%) | .98 | ||
| Caucasian | 738 (68.3) | 187 (68.2) | |
| African-American | 205 (19) | 53 (19.3) | |
| Others | 66 (6.1) | 15 (5.5) | |
| Not reported | 71 (6.6) | 19 (6.9) | |
| Disease, n (%) | .66 | ||
| Acute myelogenous leukemia | 431 (39.9) | 107 (39.1) | |
| Acute lymphoblastic leukemia | 228 (21.1) | 55 (20.1) | |
| Chronic leukemias | 78 (7.2) | 28 (10.2) | |
| Myelodysplastic syndrome | 172 (15.9) | 46 (16.8) | |
| Lymphoma | 171 (15.9) | 38 (13.8) | |
| Disease risk index, n (%) | 1.00 | ||
| Low | 114 (10.6) | 29 (10.6) | |
| Intermediate | 715 (66.2) | 181 (66.1) | |
| High | 251 (23.2) | 64 (23.4) | |
| HCT-CI, n (%) | .17 | ||
| 0 | 192 (17.8) | 36 (13.1) | |
| 1-2 | 324 (30) | 90 (32.8) | |
| ≥3 | 564 (52.2) | 148 (54) | |
| Donor/recipient CMV serostatus, n (%) | .41 | ||
| -/+ | 289 (26.8) | 76 (27.7) | |
| Other combinations | 786 (72.8) | 197 (71.9) | |
| Not reported | 5 (.5) | 1 (.4) | |
| Conditioning intensity, n (%) | .80 | ||
| Myeloablative | 515 (47.7) | 133 (48.5) | |
| Reduced-intensity/nonmyeloablative | 565 (52.3) | 141 (51.5) | |
| Donor type, n (%) | .18 | ||
| Matched related donor | 152 (14.1) | 49 (17.9) | |
| Haploidentical related donor | 659 (61) | 169 (61.7) | |
| 8/8 unrelated donor | 182 (16.9) | 34 (12.4) | |
| ≤7/8 unrelated donor | 87 (8.1) | 22 (8) | |
| Graft type, n (%) | 1.00 | ||
| BM | 71 (6.6) | 18 (6.6) | |
| PB | 1009 (93.4) | 256 (93.4) | |
| TNC dose infused in BM grafts, × 108/kg recipient body weight, median (range) | 3.1 (1.2-26.3) | 2.9 (1.8-4.6) | .85 |
| CD34+ cell dose infused in PB grafts, × 106/kg recipient body weight, median (range) | 5.3 (1-24.5) | 5.2 (1.1-13.7) | .03 |
CMV indicates cytomegalovirus; TNC, total nucleated cell.