Table 2.
Association between types of thyroid disease and end points
| End point | Hypothyroidism |
Hyperthyroidism |
No thyroid disease | Overall p value |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Unadjusted |
Adjusted‡ |
Unadjusted |
Adjusted‡ |
Unadjusted | Adjusted‡ | ||||||||
| Rate (events) | hazard ratio* (95% confidence Interval) | p value | hazard ratio* (95% confidence Interval) | p value | Rate (events) | hazard ratio* (95% confidence Interval) | p value | hazard ratio* (95% confidence Interval) | p value | Rate (events) | |||
| Stroke/systemic embolism | 1.13 (34) | 0.76 (0.51–1.13) | 0.23 | 0.76 (0.51–1.14) | 0.24 | 0.84 (5) | 0.57 (0.21–1.55) | 0.38 | 0.59 (0.21–1.60) | 0.41 | 1.48 (435) | 0.14 | 0.16 |
| Any stroke | 1.09 (33) | 0.78 (0.53–1.16) | 0.31 | 0.79 (0.53–1.20) | 0.36 | 0.50 (3) | 0.36 (0.10–1.308) | 0.15 | 0.38 (0.10–1.38) | 0.17 | 1.40 (410) | 0.09 | 0.11 |
| Ischemic stroke† | 0.99 (30) | 0.96 (0.63–1.47) | 0.98 | 0.96 (0.62–1.48) | 0.97 | 0.50 (3) | 0.49 (0.14–1.78) | 0.39 | 0.50 (0.14–1.83) | 0.40 | 1.03 (302) | 0.47 | 0.48 |
| Hemorrhagic stroke | 0.10 (3) | 0.26 (0.07–0.94) | 0.04 | 0.30 (0.08–1.11) | 0.08 | 0.00 (0) | – | – | – | – | 0.38 (114) | 0.07 | 0.12 |
| All-cause death | 3.48 (107) | 0.92 (0.73–1.15) | 0.61 | 0.91 (0.72–1.14) | 0.57 | 3.15 (19) | 0.83 (0.49–1.39) | 0.65 | 0.95 (0.57–1.61) | 0.97 | 3.81 (1145) | 0.50 | 0.63 |
| Myocardial infarction | 0.99 (30) | 1.82 (1.17–2.83) | 0.01 | 1.43 (0.90–2.26) | 0.16 | 0.17 (1) | 0.31 (0.03–2.88) | 0.42 | 0.33 (0.04–3.15) | 0.47 | 0.54 (161) | 0.01 | 0.11 |
| Heart failure hospitalization | 2.36 (71) | 1.03 (0.78–1.36) | 0.96 | 0.99 (0.74–1.31) | 0.99 | 3.27 (19) | 1.44 (0.86–2.42) | 0.22 | 1.45 (0.85–2.46) | 0.23 | 2.28 (670) | 0.29 | 0.30 |
| International Society on Thrombosis and Haemostasis major bleeding | 3.08 (82) | 1.19 (0.91–1.54) | 0.27 | 1.00 (0.76–1.31) | 1.00 | 2.22 (12) | 0.86 (0.45–1.64) | 0.84 | 0.81 (0.41–1.60) | 0.73 | 2.59 (694) | 0.29 | 0.79 |
| Any bleeding | 26.58 (558) | 1.22 (1.11–1.35) | <.0001 | 1.07 (0.96–1.19) | 0.29 | 22.79 (102) | 1.07 (0.86–1.34) | 0.75 | 1.05 (0.83–1.32) | 0.88 | 21.35 (4713) | <.0001 | 0.34 |
Hazard ratios vs no thyroid disease.
Includes unknown type of stroke.Pairwise p values and 95% confidence intervals corrected by multiplicity
Covariates included in adjusted models by outcome: Any Stroke and Ischemic Stroke: Adjusted by region, diabetes, hypertension, moderate or severe valvular heart disease, prior stroke, transient ischemic attack or systemic embolism, prior use of vitamin K antagonist >30 days, congestive heart failure, age, and weight (nonlinear).Hemorrhagic Stroke, ISTH Major Bleeding, and Any Bleeding: Adjusted by sex, region, coronary artery disease, prior myocardial infarction, history of bleeding, anemia, CHADS2 score, renal disease, and age.All-cause death: Adjusted by sex, region, hypertension, moderate or severe valvular heart disease, prior myocardial infarction, prior stroke, transient ischemic attack or systemic embolism, anemia, current smoker, prior use of vitamin K antagonist >30 days, New York Heart Association class, CHADS2 score, renal disease, congestive heart failure, age (nonlinear), systolic blood pressure (nonlinear), diastolic blood pressure (nonlinear), and weight.Myocardial Infarction: Adjusted by region, diabetes, coronary artery disease, prior myocardial infarction, New York Heart Association class, renal disease, congestive heart failure, and age (nonlinear).Heart failure hospitalization: Adjusted by diabetes, moderate or severe valvular heart disease, prior myocardial, renal disease, left bundle branch block, current smoker, New York Heart Association class, congestive heart disease, age (nonlinear), systolic blood pressure (nonlinear), and weight (nonlinear).