Table 3.

Logistic regression analysis of variables associated with the severity of COVID-19.

Variables	Univariate analysis			Multivariate analysis
	OR	95%CI	P value	OR	95%CI	P value
Age(years)	1.037	0.997-1.079	0.068
BMI (kg/m2)	1.186	1.029-1.367	0.019
Hypertension	5.201	1.745-15.508	0.003	4.380	1.012-18.993	0.048
WBC count (×109)	1.009	0.845-1.206	0.917
Neutrophil% (%)	1.062	1.012-1.116	0.015
Lymphocyte% (%)	0.932	0.877-0.989	0.021
Neutrophil count (×109/L)	1.054	0.906-1.226	0.497
Lymphocyte count (×109/L)	0.160	0.041-0.632	0.009
Platelet count (×109/L)	0.990	0.980-1.000	0.041
NLR	1.090	1.003-1.185	0.043
PLR	1.004	1.000-1.008	0.06
D-dimer (ng/ml)*	0.899	0.998-1.002	0.899
Fibrinogen (mg/dl)	1.004	1.001-1.008	0.007
Erythrocyte sedimentation rate (mm/h)a	1.015	0.996-1.034	0.118
Sialic acid (U/L)	1.049	1.011-1.088	0.011
C-reactive protein (mg/L)	1.033	1.015-1.052	<0.001	1.030	1.005-1.055	0.017
Interleukin-2 (pg/ml)	0.790	0.389-1.604	0.515
interleukin-4 (pg/ml)	1.020	0.529-1.967	0.952
Interleukin-6 (pg/ml)	1.086	1.041-1.133	<0.001	1.090	1.040-1.147	<0.001
Interleukin-10(pg/ml)	1.117	1.017-1.228	0.021
Interferon-γ (pg/ml)	0.994	0.947-1.043	0.803
Tumor Necrosis Factor-α (pg/ml)	0.917	0.386-2.182	0.845

COVID-19: coronavirus disease 2019; WBC: white blood cell; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; OR: odd ratio; CI: confidence interval.

^*The number of COVID-19 patients who tested D-dimer was 95 and 10 in the non-severe group and severe group, respectively.

^aThe number of COVID-19 patients who tested erythrocyte sedimentation rate was 97 and 12 in the non-severe group and severe group, respectively.