Figure 1.

The CC-F1 Population Exhibits Broad Between-Strain Variation in the Magnitude, Kinetics, and Composition of IAV-Specific Antibody Responses

(A) The CC-F1 population generally exhibited an overall pattern of antibody responses that is consistent with canonical antibody maturation (e.g., IgM peaking early and then waning, concurrent with a continual expansion of IgG isotypes). Bar heights represent mean raw area under the curve (AUC) values across all CC-F1s.

(B) The correlation structure of antibody isotypes and subtype responses in the F1s over time was evaluated to determine the relationship between the development of various antibody types across the population.

(C and D) Representative examples of variation in the magnitude and kinetics of IgG (C) and IgM (D), with some exceptionally notable outliers for IgM. Each point represents an individual mouse, and bars represent mean values for F1s. (D). This variation was independent of Mx1 haplotype (for both panel sets red = Mx1 −/−, blue = Mx1 +/−).

See also Figures S1–S3.