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. 2020 Apr 30;3(6):e201900521. doi: 10.26508/lsa.201900521

Figure 1. Presenilin-dependent accumulation of lipid droplets (LDs).

Figure 1.

(A) Representative fluorescence microscopy images of MEFs from wild-type (WT) and PS1/PS2 double knockout (PSdKO) mice. As controls, functional human PS1 WT or the catalytically inactive PS1 DA variant was stably expressed in PSdKO cells. Cells were co-stained with the LD540 dye and DAPI to visualize LDs and nuclei, respectively. An increase in the number of LDs was observed in cells lacking functional presenilin expression. Scale bar = 20 μm. (B) Quantification of the average amount of LDs per cell on the different genotypes. Data shown are average values ± SEM, n = 10–13. Significance was analyzed by one-way ANOVA and Holms–Sidak multiple comparison test. ***P ≤ 0.001.