Fig. 3.

(A) Representative photographs on day 7 post-infection (a) without and (b) with treatment of Cur-CQDs-180 (25 mg kg⁻¹). The red arrow indicates apparent limb paralysis in the untreated infected mice. (B) Survival rates, (C) clinical scores, and (D) body weights of (i) newborn mice without infection and (ii − iv) newborn mice intraperitoneally injected with (ii) PBS, (iii) curcumin (25 mg kg⁻¹), or (iv) Cur-CQDs-180 (25 mg kg⁻¹) followed by intraperitoneal injection of EV71 at the dose of 2 × 10⁶ PFU. A group of uninfected mice treated with sterile PBS was used as an uninfected control. The curcumin or Cur-CQDs-180 treatment was performed every 12 h daily for seven consecutive days. The mice were monitored for 15 d. (Reprinted with permission from Ref. 51 Copyright 2019 Wiley). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)