1. Baseline characteristics of included studies.
| Study | Intervention: alternative lipid emulsion | Control: conventional pure soy lipid emulsion | ||||||||
| Lipid emulsion# | n | Males |
Gestation in weeks* |
Birth weight in grams* |
Lipid emulsion | n | Males |
Gestation in weeks* |
Birth weight in grams* |
|
| Beken 2014 | 20% SMOFlipid | 40 | 24 | 30 (28‐31)** | 1092 (224) | 20% Intralipid | 40 | 22 | 30 (27‐31)** | 1160 (251) |
| D'ascenzo 2014 | 20% SMOFlipid | 39 | 24 | 27.5 (3.4) | 898.5 (309.4) | 20% Intralipid | 41 | 23 | 28.1 (3.1) | 941 (299) |
| Demirel 2011 | ClinOleic | 20 | 9 | 30.3 (2.5) | 1300.2 (480) | 20% Intralipid | 20 | 12 | 29.2 (3.5) | 1252.5 (458) |
| Deshpande 2009 | ClinOleic | 24 | 14 | 26.1 (1.3) | 848.2 (184.2) | 20% Intralipid | 21 | 10 | 25.9 (1.2) | 801.2 (210.9) |
| Gawecka 2008 | ClinOleic | 18 | 9 | 27 (1) | 936 (218) | 20% Intralipid | 20 | 9 | 27 (2) | 924 (221) |
| Gobel 2003 | ClinOleic | 24 | 18 | 31.4 (2.4) | 1577 (378) | 20% Intralipid | 21 | 11 | 32 (1.8) | 1694 (475) |
| Koksal 2011 | ClinOleic | 32 | 14 | 30.2 (1.3) | 1520 (420) | 20% Intralipid | 32 | 16 | 30.4 (1.6) | 1460 (280) |
| Lehner 2006 | 20% Lipofundin (MCT) | 6 | 6 | 31.4 (1.6) | 1573.3(169.8) | 20% Lipofundin N | 6 | 3 | 33.2 (1.0) | 1781.7 (290.3) |
| Rayyan 2012 | 20% SMOFlipid | 26 | 8 | 29.9 (1.9) | 1335.6 (408.8) | 20% Intralipid | 27 | 16 | 30.4 (1.8) | 1364.1 (339.7) |
| Rubin 1994 | 20% Lipofundin (MCT) | 15 | 11 | 31.6 (2.3) | 1570 (400) | 20% Intralipid | 18 | 11 | 31.4 (2.1) | 1420 (400) |
| Rubin 1994 | PFE 4501 | 16 | 9 | 30.5 (2.7) | 1390 (500) | |||||
| Savini 2013 | Lipofundin (MCT) | 30 | 14 | 27.7 (1.8) | 937 (222) | 20% Intralipid | 30 | 13 | 28.3 (2.1) | 955 (202) |
| Savini 2013 | Lipidem (MFS) | 27 | 14 | 28.3 ( 2.3) | 935 (202) | |||||
| Savini 2013 | ClinOleic | 29 | 13 | 27.7 (2.4) | 905 (160) | |||||
| Savini 2013 | SMOFlipid | 28 | 12 | 27.6 (2) | 898 (199) | |||||
| Skouroliakou 2010 | 20% SMOFlipid | 14 | NA | 28.21 (2.9) | 1140 (260) | 20% Intralipid | 18 | NA | 30.3 (1.5) | 1210 (170) |
| Tomsits 2010 | 20% SMOFlipid | 30 | NA | 31.7 (1.90) | 1661.7 (418) | 20% Intralipid | 30 | NA | 31.9 (1.8) | 1676.7 (411.5) |
| Vlaardingerbroek 2014 | 20% SMOFlipid | 48 | 23 | 27.1 (2.3) | 855 (226) | 20% Intralipid | 48 | 18 | 27.2 (1.9) | 888 (204) |
| Wang 2015 | ClinOleic | 50 | 26 | 32.20 (1.7) | 1486.6 (253.8) | 20% Intralipid | 50 | 31 | 30.8 (4.9) | 1469.8 (250.5) |
# Please refer to Appendix 1 for details of the constituents of lipid emulsions NA: not available * gestation and birth weight are presented as mean (SD) ** median (range) Rubin 1994 had 3 intervention arms and Savini 2013 had 5 intervention arms; total enrolled infants (n = 979) were more than the total number of infants for which the baseline characteristics and results were available (due to withdrawals) n: number of infants for whom the baseline characteristics were known