Comparison 2. MFS‐LE versus S‐LE.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Death before discharge	1	60	Risk Ratio (M‐H, Fixed, 95% CI)	5.00 [0.25, 99.95]
2.2 Days to regain birth weight	1	57	Mean Difference (IV, Fixed, 95% CI)	‐1.00 [‐3.60, 1.60]
2.3 Rate of weight gain (g/kg/day)	1	57	Mean Difference (IV, Fixed, 95% CI)	‐1.67 [‐7.01, 3.67]
2.4 Bronchopulmonary dysplasia/chronic lung disease	1	57	Risk Ratio (M‐H, Fixed, 95% CI)	1.39 [0.42, 4.65]
2.5 Any sepsis (clinical and/or culture positive)	1	57	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [0.31, 4.02]
2.6 Necrotising enterocolitis (≥ stage 2)	1	57	Risk Difference (M‐H, Fixed, 95% CI)	0.00 [‐0.07, 0.07]
2.7 Any patent ductus arteriosus	1	57	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.57, 1.64]
2.8 Parenteral nutrition associated liver disease/cholestasis	1	57	Risk Ratio (M‐H, Fixed, 95% CI)	3.32 [0.14, 78.25]