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. 2015 Dec 2;2015(12):CD009172. doi: 10.1002/14651858.CD009172.pub2

Comparison 9. All alternative LE versus S‐LE.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
9.1 Death before discharge 7 623 Risk Ratio (M‐H, Fixed, 95% CI) 1.17 [0.66, 2.07]
9.2 Days to regain birth weight 5 484 Mean Difference (IV, Fixed, 95% CI) 0.53 [‐0.52, 1.58]
9.3 Rate of weight gain (g/kg/day) 6 497 Mean Difference (IV, Fixed, 95% CI) 0.68 [‐0.19, 1.55]
9.4 Bronchopulmonary dysplasia/chronic lung disease 7 602 Risk Ratio (M‐H, Fixed, 95% CI) 0.84 [0.63, 1.12]
9.5 Duration of ventilation (days) 6 410 Mean Difference (IV, Fixed, 95% CI) ‐0.27 [‐1.60, 1.06]
9.6 Duration of supplemental oxygen (days) 4 242 Mean Difference (IV, Fixed, 95% CI) 0.44 [‐2.01, 2.89]
9.7 Need for home oxygen therapy 1 64 Risk Difference (M‐H, Fixed, 95% CI) 0.00 [‐0.06, 0.06]
9.8 Culture positive sepsis 3 244 Risk Ratio (M‐H, Fixed, 95% CI) 1.08 [0.52, 2.26]
9.9 Any sepsis (clinical and/or culture positive) 9 674 Risk Ratio (M‐H, Fixed, 95% CI) 0.90 [0.66, 1.23]
9.10 Necrotising enterocolitis (≥ stage 2) 4 400 Risk Ratio (M‐H, Fixed, 95% CI) 1.34 [0.67, 2.67]
9.11 Significant jaundice requiring treatment 2 109 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.52, 2.07]
9.12 Duration of phototherapy (days) 2 70 Mean Difference (IV, Fixed, 95% CI) ‐0.09 [‐1.00, 0.83]
9.13 Retinopathy of prematurity (≥ stage 3) 3 256 Risk Ratio (M‐H, Fixed, 95% CI) 0.43 [0.06, 2.85]
9.14 Intraventricular haemorrhage (grade III‐IV) 5 360 Risk Ratio (M‐H, Fixed, 95% CI) 0.90 [0.48, 1.70]
9.15 Periventricular leukomalacia 3 240 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 7.89]
9.16 Any patent ductus arteriosus 3 320 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.75, 1.23]
9.17 Significant patent ductus arteriosus requiring treatment 1 96 Risk Ratio (M‐H, Fixed, 95% CI) 0.83 [0.52, 1.31]
9.18 Air leaks 1 64 Risk Ratio (M‐H, Fixed, 95% CI) 0.50 [0.05, 5.24]
9.19 Parenteral nutrition associated liver disease/cholestasis 7 602 Risk Ratio (M‐H, Fixed, 95% CI) 0.83 [0.37, 1.86]
9.20 Hypertriglyceridaemia 4 212 Risk Ratio (M‐H, Fixed, 95% CI) 0.95 [0.59, 1.54]
9.21 Hyperglycaemia 3 176 Risk Ratio (M‐H, Fixed, 95% CI) 0.95 [0.37, 2.46]
9.22 Hypoglycaemia 1 80 Risk Ratio (M‐H, Fixed, 95% CI) 0.14 [0.01, 2.68]