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. 2015 Dec 2;2015(12):CD009172. doi: 10.1002/14651858.CD009172.pub2
Decision to downgrade Risk of bias across studies for an outcome
Do not downgrade Most information is from studies at low risk of bias
Downgrade 1 level Most information is from studies at moderate risk of bias
Downgrade 2 levels Most information is from studies at high risk of bias