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. 2015 Dec 2;2015(12):CD009172. doi: 10.1002/14651858.CD009172.pub2
Decision matrix
for inconsistency 		Heterogeneity I2 > 40% (40%‐74%) Unexplained high heterogeneity
with I2 > 75 % and very low P value
Same direction of
effect estimates
in the studies 		May not downgrade 1 level if most
of the studies have similar point estimates
and overlapping CI AND all point estimates
are pointing in the same direction.		 Downgrade 1 level
Different direction
of effect estimates
in the studies 		Downgrade 1 level Downgrade 2 levels