Table 1.
Baseline Patient Characteristics by Diastolic Dysfunction Status
| Diastolic Dysfunction Absent (N=101) | Diastolic Dysfunction Present (N=94) | P Value | |
|---|---|---|---|
| Age | 52.5 ± 5.7 | 58.0 ± 8.1 | <0.01 |
| Women | 29 (29) | 27 (29) | 0.99 |
| Race | 0.46 | ||
| White | 42 (42) | 44 (47) | |
| Black | 59 (58) | 50 (53) | |
| Other | 0 (0) | 0 (0) | |
| Hispanic ethnicity | 4 (4) | 4 (4) | 1.00 |
| Vital sign and exam findings | |||
| Systolic blood pressure (mmHg) | 124 (116, 134) | 130 (122, 143) | <0.01 |
| Diastolic blood pressure (mmHg) | 80 (71, 84) | 82 (75, 88) | <0.01 |
| Heart rate (bpm) | 73 (65, 81) | 75 (66, 84) | 0.04 |
| Weight (lbs) | 179 (152, 198) | 195 (168, 227) | <0.01 |
| BMI (kg/m2) | 26.6 (24.3, 30.4) | 28.4 (25.5, 34.2) | 0.01 |
| Jugular venous distention | 1 (1) | 2 (2) | 0.61 |
| Peripheral edema | 0.10 | ||
| None | 95 (97) | 83 (91) | |
| Trace | 1 (1) | 4 (4) | |
| Mild (1+) | 1 (1) | 3 (3) | |
| Moderate (2+/3+) | 1 (1) | 1 (1) | |
| Severe (4+) | 0 (0) | 0 (0) | |
| Rhythm on ECG | 0.54 | ||
| Sinus rhythm | 90 (90) | 82 (87) | |
| Atrial fibrillation/flutter | 0 (0) | 0 (0) | |
| Other | 10 (10) | 12 (13) | |
| QRS Duration | 86 (80, 96) | 90 (82, 97) | 0.04 |
| Non-HIV Related Laboratories | |||
| Sodium (mEq/L) | 139 (138, 141) | 140 (138, 142) | 0.18 |
| BUN (mg/dL) | 13 (11, 18) | 15 (13, 19) | 0.09 |
| Creatinine (mg/dL) | 1.0 (0.8, 1.2) | 1.1 (0.9, 1.2) | <0.01 |
| Albumin (g/dL) | 4.3 (4.0, 4.5) | 4.2 (4.0, 4.4) | 0.57 |
| ALT (IU/L) | 23 (15, 33) | 22 (16, 32) | 0.91 |
| Total Bilirubin (mg/dL) | 0.4 (0.3, 0.6) | 0.5 (0.3, 0.7) | 0.51 |
| HbA1c (%) | 5.5 (5.1, 6.7) | 5.7 (5.4, 6.3) | 0.22 |
| Hemoglobin (g/dL) | 13.8 (13.2, 15.0) | 13.8 (13.0, 15.2) | 0.76 |
| LDL (mg/dL) | 105 (88, 120) | 104 (82, 119) | 0.95 |
| HDL (mg/dL) | 49 (41, 60) | 46 (38, 57) | 0.13 |
| Triglycerides (mg/dL) | 124 (82, 154) | 121 (97, 198) | 0.19 |
| HIV Related Laboratories | |||
| CD4 Count (cells/mm3) | 680 (469, 838) | 668 (416, 836) | 0.84 |
| Nadir CD4 Count (cells/mm3) | 319 (184, 447) | 269 (80, 450) | 0.48 |
| CD8 Count (cells/mm3) | 710 (416, 936) | 838 (568, 1158) | 0.02 |
| CD4/CD8 Ratio | 1.0 (0.7–1.4) | 0.8 (0.5, 1.2) | 0.14 |
| HIV RNA (copies/mL)* | 27.3 ± 12.8 | 28.1 ± 16.3 | 0.74 |
| Non-HIV Related Medical History | |||
| Heart failure diagnosis | 2 (2) | 8 (9) | 0.05 |
| Prior MI | 1 (1) | 2 (2) | 0.61 |
| Hypertension | 38 (38) | 59 (63) | <0.01 |
| Hyperlipidemia | 21 (21) | 41 (44) | <0.01 |
| Stroke | 2 (2) | 7 (7) | 0.09 |
| Diabetes | 11 (11) | 19 (20) | 0.07 |
| Chronic renal insufficiency | 2 (2) | 14 (15) | <0.01 |
| Cancer (non-AIDS associated) | 6 (6) | 12 (11) | 0.13 |
| Illicit drug use | 39 (39) | 31 (34) | 0.41 |
| Smoking history | 64 (63) | 49 (53) | 0.13 |
| HIV Related Medical History | |||
| Duration of HIV Diagnosis (years) | 15.2 (9.9, 22.2) | 16.5 (9.4, 22.4) | 0.44 |
| Hepatitis B | 4 (4) | 9 (10) | 0.11 |
| Hepatitis C | 14 (14) | 13 (14) | 0.98 |
| HIV-associated Cancer | 1 (1) | 3 (3) | 0.35 |
| Pneumocystis Jiroveci | 11 (11) | 4 (4) | 0.08 |
| Candida Esophagitis | 5 (5) | 11 (10) | 0.14 |
| CMV Infection Diagnosed by | 5 (5) | 2 (2) | 0.45 |
| Histopathology | |||
| Pulmonary Tuberculosis | 4 (4) | 2 (2) | 0.68 |
| Extrapulmonary Cryptococcal Infection | 2 (2) | 2 (2) | 1.00 |
Data presented as n (%), mean ± standard deviation, or median (25th, 75th).
ALT, alanine aminotransferase; BMI, body mass index; BUN, blood urea nitrogen; CMV, cytomegalovirus; ECG, electrocardiogram; HDL, high-density lipoprotein; HIV, human immunodeficiency virus; HBA1c, hemoglobin A1c; LDL, low-density lipoprotein; MI, myocardial infarction; RNA, ribonucleic acid.
Mean viral load data only among patients with detectable values (DD+, n=20; DD−, n=15). Overall, the assay level of detection was available for 160 total patients. Overall, 118 patients were tested with an assay detection threshold of 20 copies/mL, 1 patient with an assay detection threshold of 30 copies/mL, and 41 patients with an assay detection threshold of 40 copies/mL. All patients in CHART had a viral load <200 copies/mL.