Table 4.
Serum Biomarker Profile by Diastolic Dysfunction Status
| Biomarker Domain | Diastolic Dysfunction Absent (N=101) | Diastolic Dysfunction Present (N=94) | P Value |
|---|---|---|---|
| Ventricular wall stress | |||
| NT-proBNP (pg/mL) | 26.2 (12.0, 46.8) | 36.1 (22.7, 85.3) | <0.01 |
| NT-proBNP >100 pg/mL | 9 (9) | 20 (21) | 0.01 |
| Myocardial injury | |||
| High-sensitivity troponin I (pg/mL) | 2.5 (1.8, 3.5) | 3.6 (2.6, 5.1) | <0.01 |
| High-sensitivity troponin I >3.0 pg/mL | 37 (37) | 56 (61) | <0.01 |
| Inflammation | |||
| hs-CRP (ug/mL) | 1.6 (0.8, 4.0) | 2.4 (1.1, 5.7) | 0.11 |
| IL-6 (pg/mL) | 0.9 (0.5, 1.3) | 1.0 (0.7, 1.6) | 0.08 |
| Oxidized LDL (U/L) | 55.3 (44.6, 62.1) | 57.0 (50.4, 69.1) | 0.07 |
| Cardiac fibrosis and remodeling | |||
| CITP (ug/L) | 3.7 (2.9, 4.8) | 4.1 (3.2, 5.7) | 0.04 |
| ST-2 (ng/mL) | 22.4 (18.7, 27.0) | 23.1 (19.4, 27.0) | 0.54 |
| Galactin-3 (ng/mL) | 9.7 (8.0, 12.2) | 10.6 (8.6, 13.4) | 0.15 |
| GDF-15 (pg/mL) | 734.8 (569.5, 1078.4) | 867.2 (627.5, 1385.2) | 0.07 |
| GDF-15 >1000pg/mL | 30 (30) | 38 (40) | 0.12 |
| MMP-1 (pg/mL) | 6463.0 (4021.0, 9909.0) | 6068.4 (3803.2, 9525.0) | 0.62 |
| Oxidative stress | |||
| Myeloperoxidase (ng/mL) | 19.4 (14.9, 27.0) | 20.8 (14.2, 32.7) | 0.90 |
| Immune activation | |||
| Classic monocytes (%) | 58.6 (46.1, 68.1) | 59.1 (51.4, 69.5) | 0.66 |
| Intermediate monocytes (%) | 4.6 (3.1, 6.7) | 5.1 (3.2, 6.9) | 0.67 |
| Non-classic monocytes (%) | 4.8 (2.8, 7.5) | 4.5 (2.8, 8.0) | 0.72 |
| sCD163 ng/mL | 553.1 (430.1, 787.7) | 602.7 (445.8, 816.1) | 0.24 |
| sCD14 (ng/mL | 2003.1 (1702.9, 2301.6) | 1942.7 (1688.4, 2220.9) | 0.49 |
| CD4+/CD38+ cells (%) | 37.1 (23.4, 51.4) | 33.4 (24.9, 40.7) | 0.07 |
| CD4+/HLADR+ cells (%) | 15.5 (11.4, 19.3) | 15.5 (12.4, 19.1) | 0.50 |
| CD4+/IFNg+ cells (%) | 16.8 (12.8, 22.4) | 20.5 (14.9, 27.2) | <0.01 |
| CD4+/IL-4+ cells (%) | 3.2 (2.1, 4.7) | 3.1 (2.1, 4.4) | 0.95 |
| CD4+/IL-17+ cells (%) | 2.0 (1.4, 3.4) | 2.2 (1.5, 2.9) | 0.64 |
| CD8+/CD38+ cells (%) | 13.7 (9.6, 20.9) | 13.5 (9.2, 17.6) | 0.50 |
| CD8+/HLADR+ cells (%) | 17.7 (13.0, 23.3) | 21.4 (14.4, 29.9) | 0.03 |
| CD8+/IFNg+ cells (%) | 42.5 (31.2, 51.9) | 47.6 (35.9, 58.0) | 0.06 |
| CD8+/IL-4+ cells (%) | 2.8 (1.9, 3.7) | 2.6 (2.0, 3.3) | 0.85 |
| CD8+/IL-17+ cells (%) | 1.7 (1.0, 2.5) | 1.5 (0.8, 2.5) | 0.35 |
Data presented as n (%) or median (25th, 75th).
CITP, C-terminal telopeptide of collagen I; GDF-15, growth differentiation factor 15; hs-CRP, high sensitivity C-reactive protein; IL, interleukin; LDL, low density lipoprotein; MMP, matrix metalloproteinases; NT-proBNP, N-terminal pro-B-type natriuretic peptide; ST-2, suppression of tumorigenicity-2