Table 2:

Cytochrome P-450 (CYPs) and drug metabolism

Gene	Role	Drug(s) Affected
CYP2D6	Metabolism of 25% of all drugs	Antidepressants, antipsychotics, beta blockers, opioids
CYP2C9	Metabolism of 10% of all drugs	Warfarin, NSAIDs, sulfonylureas, phenytoin
CYP2C19	Metabolism of 10–15% of all drugs	Clopidogrel, proton pump inhibitors, citalopram, diazepam
CYP1A2	Metabolism of 9% of all drugs	Clozapine, olanzapine, theophylline, caffeine
CYP3A4/3A5	Metabolism of 50% of all drugs	Statins, benzodiazepenes, antibiotics, antipsychotics
SLC6A4	Serotonin transporter	SSRIs
OPRM1	Mu opioid receptor	Hydromorphone, morphine, oxymorphone, other opioid agonists
VKORC1	Vitamin K clotting cascade	Warfarin (sensitivity)
SLCO1B1	Transport of statins in liver	Statins
Factor V (Leiden)	Clotting factor V	Oral contraceptives
COMT	Dopamine and norepinephrine degradation	Stimulatory therapies