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. 2019 Oct 16;29(23):126717. doi: 10.1016/j.bmcl.2019.126717

Fig. 3.

Fig. 3

Overlay of CypD X-ray structures in complex with 14 (orange, PDB-ID: 6R8O) and 16 (magenta, PDB-ID: 6R8L) at 1.4 Å and 1.6 Å resolution respectively. H-bonds are displayed as dashed lines (hydrogen atoms are omitted and only water molecules in H-bond contact to the inhibitors are shown for clarity). The different stereochemistry of the bicyclic rings results in altered H-bond networks involving the OH-groups and water molecules 1 and 2.