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. 2020 May 1;5:33. doi: 10.1038/s41541-020-0183-8

Fig. 4. Immunogenicity of OspA-ferritin nanoparticles in rhesus monkeys.

Fig. 4

Immunogenicity of OspA-ferritin nanoparticle vaccines in rhesus monkeys (a). Rhesus monkeys (n = 3 per group) were immunized intramuscularly at week 0 and week 6 with the molar equivalent of 10 µg of each OspA-ferritin serotype (total 60 µg) with AF03 adjuvant and ELISA titers were analyzed 2 weeks later. RecombitekTM was given at 10 µg dose. The ELISA plate was coated with the OspA serotype indicated in each panel. Time course of endpoint antibody titer in Rhesus monkeys (b). Indian rhesus macaques (n = 3 per group) were immunized intramuscularly at week 0 and week 6 with the molar equivalent of 10 µg of each OspA-ferritin serotype (total 60 µg) with AF03 adjuvant. RecombitekTM was given at a 10 µg dose. The ELISA plate was coated with OspA serotype 1.