Table 1.
Top association SNPs for independent loci for WMH meta-analysis.
| CHR:BP | rsID | A1/A2 | A1_FREQ | WMH_P | FA_P | MD_P | HGNC genes | Novel |
|---|---|---|---|---|---|---|---|---|
| 1:197499003 | rs12120143 | T/C | 0.03 | 6.45 × 10−09 | 3.78 × 10−02 | 3.79 × 10−01 | DENND1B | Yes |
| 2:43118872 | rs7566761 | A/G | 0.20 | 7.62 × 10−13 | 1.95 × 10−01 | 6.57 × 10−01 | AC098824.6a | No |
| 2:56128091 | rs7596872 | A/C | 0.10 | 2.06 × 10−20 | 3.92 × 10−01 | 1.48 × 10−02 | EFEMP1 | No |
| 2:188003118 | rs17576323 | C/T | 0.20 | 3.15 × 10−08 | 3.38 × 10−01 | 6.92 × 10−01 | AC007319.1 | Yes |
| 2:203916487 | rs72934505 | G/T | 0.13 | 4.31 × 10−13 | 7.34 × 10−08 | 7.28 × 10−05 | ICA1L, WDR12, CARF, NBEAL1, CYP20A1 | No |
| 3:183380035 | rs830179 | A/G | 0.32 | 4.67 × 10−09 | 3.21 × 10−01 | 1.11 × 10−03 | KLHL24 | Yes |
| 5:121510586 | rs17148926 | C/A | 0.17 | 4.07 × 10−09 | 1.54 × 10−03 | 4.46 × 10−05 | CTC-441N14.4 | Yes |
| 6:151016058 | rs275350 | C/G | 0.41 | 8.83 × 10−17 | 3.96 × 10−03 | 4.54 × 10−05 | PLEKHG1 | No |
| 7:100361391 | rs3215395 | ID/G | 0.29 | 2.18 × 10−08 | 1.21 × 10−02 | 4.42 × 10−03 | ZAN | Yes |
| 10:105459116 | rs4630220 | A/G | 0.29 | 1.21 × 10−14 | 2.88 × 10−03 | 3.32 × 10−05 | SH3PXD2A | No |
| 13:111040681 | rs11838776 | A/G | 0.28 | 7.90 × 10−11 | 1.97 × 10−01 | 1.03 × 10−02 | COL4A2 | No |
| 14:100581636 | rs11160570 | T/C | 0.26 | 6.10 × 10−13 | 1.09 × 10−02 | 3.19 × 10−05 | EVL, DEGS2 | No |
| 15:65326833 | rs12906662 | A/T | 0.47 | 6.42 × 10−09 | 8.81 × 10−01 | 1.85 × 10−01 | MTFMT, SLC51B | Yes |
| 16:51451683 | rs17616633 | T/C | 0.44 | 7.33 × 10−11 | 2.01 × 10−01 | 4.97 × 10−02 | RP11-437L7.1a | Yes |
| 16:87237568 | rs12928520 | T/C | 0.44 | 1.26 × 10−13 | 8.18 × 10−01 | 2.10 × 10−01 | C16orf95 | Yes |
| 17:19224397 | rs6587216 | G/C | 0.19 | 8.01 × 10−09 | 1.72 × 10−01 | 1.57 × 10−02 | EPN2 | Yes |
| 17:43128906 | rs8071429 | T/A | 0.37 | 2.61 × 10−16 | 9.17 × 10−05 | 4.14 × 10−06 | DCAKD, NMT1 | No |
| 17:73882148 | rs7214628 | G/A | 0.19 | 4.99 × 10−36 | 1.06 × 10−01 | 1.75 × 10−03 | WBP2, TRIM47, TRIM65 | No |
| 19:45411941 | rs429358 | C/T | 0.15 | 1.15 × 10−09 | 1.87 × 10−02 | 6.92 × 10−04 | APOE | Yes |
CHR:BP chromosome and position in bp, rsID the SNP ID, A1/A2, tested and non-tested alleles (ID is for insertion/deletions), A1_FREQ the allele frequency of the tested allele in the UK Biobank population for WMH, WMH_P, FA_P and MD_P the p-values for WMH, FA and MD respectively, HGNC genes the nearest genes to the lead SNP and its proxies (r2 ≥ 0.8), genes symbols are in italic to comply with the nomenclature, Novel this column indicated if the association has already been described in previous GWAS.
aThe lead SNP and/or proxies lie in an intergenic region.