Table 2.

Top association SNPs for independent loci for FA and MD GWAS.

CHR:BP	rsID	A1/A2	A1_FREQ	WMH_P	FA_P	MD_P	HGNC genes	Novel
2:203664929	rs76122535	G/C	0.13	2.68 × 10−12	5.57 × 10−09	4.02 × 10−06	ICA1L, WDR12, CARF, NBEAL1	Yes
2:217325317	rs34380167	ID/C	0.27	2.81 × 10−02	1.16 × 10−08	8.98 × 10−05	SMARCAL1, RPL37A	Yes
5:82862328	rs35544841	ID/G	0.20	6.89 × 10−07	2.72 × 10−25	1.80 × 10−34	VCAN	No
5:139719991	rs4150221	C/T	0.26	8.30 × 10−01	1.39 × 10−09	4.40 × 10−08	HBEGF	Yes
6:26979765	rs374598428	ID/C	0.14	2.78 × 10−02	1.52 × 10−8	2.01 × 10−07	LINC00240, VN1R12P	Yes
6:28719755	rs1233587b	T/A	0.30	1.36 × 10−01	1.67 × 10−07	5.75 × 10−12	ZFP57a	Yes
6:29155749	rs3129171b	A/G	0.24	6.65 × 10−03	1.67 × 10−09	3.79 × 10−09	ZFP57a, OR2J2, OR2H4P, XXbac-BPG308J9.3	Yes
6:31329092	rs7772614	A/C	0.38	1.93 × 10−02	3.54 × 10−05	8.44 × 10−10	HLA-B, HLA-S	Yes
10:105682296	rs11813268	T/C	0.15	6.17 × 10−04	5.62 × 10−05	7.31 × 10−09	STN1	Yes
16:89951460	rs112730611	T/C	0.17	1.27 × 10−02	1.36 × 10−09	3.86 × 10−06	SPIRE2, TCF25	Yes
17:44013964	rs55939347	ID/T	0.22	2.49 × 10−04	2.98 × 10−04	1.84 × 10−08	LINC02210-CRHR1, MAPT-AS1, MAPT, KANSL1	Yes
20:61154871	rs6062264	T/C	0.28	8.53 × 10−02	1.02 × 10−08	6.77 × 10−02	MIR1-1HG	Yes

CHR:BP chromosome and position in bp, rsID the SNP ID, A1/A2, tested and non-tested alleles (ID is for insertion/deletions), A1_FREQ the allele frequency of the tested allele in the UK Biobank population for WMH, WMH_P, FA_P and MD_P the p-values for WMH, FA and MD respectively, HGNC genes the nearest genes to the lead SNP and its proxies (r²≥ 0.8), genes symbols are in italic to comply with the nomenclature, Novel this column indicated if the association has already been described in previous GWAS.

^aThe lead SNP and/or proxies lie in an intergenic region.

^bAssociated SNPs for different traits which are in LD: rs1233587/rs3129171 (r² = 0.42).