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. 2020 May 1;3:206. doi: 10.1038/s42003-020-0937-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Circos illustrating shared genetic signal between cis- and trans-regulated genes; trans-regulated genes showing shared genetic signal with cis-regulated SH2B3 (cyan), IREB2 (yellow), and FES (red). b Single-cell gene expression (GEO accession number GSE94820) analysis showing CellPhoneDB predicted ligand–receptor interactions between monocytes and dendritic cells (DCs); on the y-axis, molecules identified as lifespan trans-QTLs are underlined; molecules expressed by monocytes and DCs are represented in yellow and blue, respectively. c Graphic representation of predicted molecular interactions between monocytes and DCs and including lifespan trans-eQTLs.