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. 2020 May 1;3:206. doi: 10.1038/s42003-020-0937-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Venn diagram of blood cis-eGenes associated with cerebrovascular accident, cardiovascular diseases, and chronic kidney diseases (CKDs). b Blood cis-eGenes disease network showing centrality of cerebrovascular accident and cardiovascular diseases. c Chart indicating the consistency in the directional effect of the cis-regulation on risk factors/disorders and the lifespan derived from Mendelian randomization analyses; blue: concordant (e.g. the cis-regulated eGene that decreased the risk of disorder/risk factor increased the lifespan), orange: non-concordant (e.g. the cis-regulated eGene that decreased the risk of disorder/risk factor decreased the lifespan). Blue and orange square P < 0.05, *P < 0.05 (FDR), **P < 1.27 × 10⁻⁴ (Bonferroni). AF: atrial fibrillation, CKD: chronic kidney disease, T2D: type 2 diabetes, BMI: body mass index, WC: waist circumference, RA: rheumatoid arthritis, T1D: type 1 diabetes, SLE: systemic lupus erythematosus, PSC: primary sclerosing cholangitis. d Forest plot of genes found to be causally associated with long-livedness (≥90 years).