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. 2020 May 1;11:2123. doi: 10.1038/s41467-020-15915-4

Fig. 2. Altered gene expression profile in human and murine Schwann cells (SCs) upon injury.

Fig. 2

qPCR analysis in human (red line) and murine (grey line) nerve explants at different time point after injury for genes typically expressed in differentiated (a–d) or repair SCs (e–h). Expression at 0 h was set to one and the fold change was calculated for the time points post injury (TPI). Graphs show for each time point mean with SEM. Two-sided Mann–Whitney test was used to calculate statistical significance (*P < 0.05, **P < 0.005, ***P < 0.001). Grey or red asterisks indicate significance compared to 0 h time point for murine or human samples respectively. Blue asterisks indicate significant differences between mouse and human for the particular time point. Biological replicates: n at 0 h, 2 h, 24 h and 48 h was 7, 7, 7 and 4 for murine nerves respectively, 26, 26, 25 and 14 for human nerves in a, b, e and f, and 17, 17, 17, 11 in c, d, g and h. Source data are provided as a Source Data file.