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. 2020 May 1;11:2123. doi: 10.1038/s41467-020-15915-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Volcano plots of differentially regulated genes in human (a) or murine nerves (b) 2 h upon injury compared to uninjured nerves. Blue numbers indicate the number of more than two-fold down (left side) or up (right side) regulated genes. c Fold change expression of selected IEGs in murine/human nerve explants at 2 h and 24 h after injury compared to 0 h. d, e Volcano plots of differentially regulated genes in human (d) or murine nerves (e) 24 h upon injury compared to uninjured nerves. f GO (Gene ontology) terms related to immune responses were significantly altered in human and murine nerves 24 h upon injury. Source data are provided as a Source Data file. g Fold change expression of selected inflammation-related genes in murine/human nerves at 2 h and 24 h after injury compared to 0 h. Fold change in c and g was calculated from the mean normalised intensities irrespective of significance. Significantly changed values are depicted in bold. h, i TF binding motif enrichment analysis for genes significantly up-regulated at least threefold in murine nerves 2 h and 24 h (h) and for human nerves 24 h (i) after injury. P-values were calculated by Pscan Ver. 1.5 software using a two-tailed Z-test.Analysed biological replicates in a–i: human n = 5, murine n = 3 for each time point.