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. 2020 May 1;11:2132. doi: 10.1038/s41467-020-16009-x

Fig. 1. Differential expression of Kng genes in tissues.

Fig. 1

a Representation of the Kng system. LMWK, low molecular weight kininogen; HMWK, high molecular weight kininogen; Kl, kallidin; Bk, bradykinin; Dkl, [Des-Arg9]-kallidin; Dbk, [Des-Arg9]-bradykinin; B2, kinin B2 receptor; B1, kinin B1 receptor. b mRNA expression of the different Kngs in iBAT, iWAT and liver of 2 months old Swiss mice (n = 5 animals; except for iWAT Kng2 HMWK and LMWK left graph where n = 4). mRNA expression of Kngs in fat depots and liver of 2 months old Swiss mice exposed to cold or control room temperature for 1 week (n = 5 animals). c KNG2 protein expression in iBAT and iWAT of mice exposed to RT or 4 °C (n = 3 animals). d KNG1 and -2 protein expression in plasma of WT mice exposed to cold for 1 week (n = 4 animals; except for KNG1 4 °C where n = 3). ND, not detectable; NS, not significant. Data are presented as means ± s.e.m. (bars). *P < 0.05, **P < 0.01, and ***P < 0.001 versus corresponding controls. P-values determined by two ways ANOVA with Tukey’s post hoc test (b left) and two-tailed unpaired Student’s t-test (b right, c, d). Source data are provided as a Source data file.