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. 2020 May 1;11:2139. doi: 10.1038/s41467-020-15975-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Variation of hydrodynamic size of the polymer with molecular weight. Mega HPGs and their low molecular weight counterparts (first four data points), and PAMAM dendrimers are compact in size compared to PEG polymers. The values for high molecular weight HPGs (76.5, 307, and 771 kDa) are obtained from literature⁶⁴. For PEGs, the size of PEG-4 (11 MDa) was derived from R_g and simulation studies⁶³. b Dependence of intrinsic viscosity of the polymers with molecular weight (arrow shows the representative y-axis). Mega HPGs showed similar intrinsic viscosity behavior as that of PAMAM dendrimers; however, slight increment with molecular weight might was observed. The PEG systems showed liner dependency with molecular weight.