Figure 1.
Kaplan-Meier Survival Curves
Comparison of survival curves for athymic mice with an orthotopic human glioma treated with PBS (group 5), 3.5 × 107 PFU of rQNestin34.5v.2 (group 6), or 3.5 × 107 PFU of rQNestin34.5v.2 with CPA pre-administration, 2 days before virus injection. Animals scheduled to undergo scheduled necropsy at day 4 or 31 are not included. In group 7, there were 10 mice that underwent scheduled necropsy at day 4 and 4 that underwent scheduled necropsy at day 31. One mouse was still alive at the study termination and underwent scheduled necropsy at this time (included in graph). For group 6, there were 10 mice that underwent scheduled necropsy at days 4 and 7 that underwent scheduled necropsy at day 31. Two mice were still alive at study termination and underwent scheduled necropsy at this time (included in graph). For group 5, there were 10 mice that underwent scheduled necropsy at day 4, but none was alive for the day 31 and thereafter scheduled necropsies. There was a statistically significant increase in survival of animals from group 6 and 7 when compared to those from group 5 (p < 0.0001, log-rank test).