Table 1.
Days 4, 31, and 61 rQNestin34.5v.2-Positive Results in Brain: Toxicity Assessment of Groups Administered rQNestin34.5v.2
| Group | Day 4 |
Day 31 |
Day 61 |
|||
|---|---|---|---|---|---|---|
| Animal ID | Copies/μg DNA | Animal ID | Copies/μg DNA | Animal ID | Copies/μg DNA | |
| 4.2 × 104 PFU virus(group 3) | 301 | 8.8 × 103 | 308 | 5.9 × 103 | 313 | 1.2 × 102 |
| 303 | 8.6 × 103 | 310 | 1.3 × 103 | 318 | 8.5 × 102 | |
| 305 | 1.2 × 104 | 311 | 1.9 × 103 | |||
| 351a | 9.2 × 103 | 357 | 2.2 × 103 | 363 | 4.2 × 102 | |
| 353b | 6.0 × 104 | 360 | 1.9 × 103 | 366 | 8.4 × 101 | |
| 355 | 4.4 × 104 | 362 | 1.5 × 103 | 368 | 5.2 × 102 | |
| 3 × 103 PFU virus + CPA (group 4) |
401 | 8.4 × 102 | 407 | 4.4 × 101 | 414 | 3.3 × 103 |
| 403 | 4.6 × 103 | 409 | 1.8 × 102 | 416 | not detected | |
| 405 | 8.0 × 103 | 412 | not detected | 417 | 9.6 × 101 | |
| 451 | 1.2 × 103 | 457 | 5.8 × 102 | 463 | not detected | |
| 453 | 1.7 × 103 | 460 | 1.1 × 102 | 465 | not detected | |
| 455 | 2.1 × 103 | 462 | 1.4 × 102 | 468 | not detected | |
a
rQNestin34.5v.2 was also detected in the kidney.
b
rQNestin34.5v.2 was also detected in the heart.