Fig. 4.

Protective efficacy of MTBVAC, MTBVAC-L2 and MTBVAC-L3 in C3H/HeNRj mice against challenge with strains from modern lineages of M. tuberculosis. The graphs represent bacterial burden in lungs (left panels) and spleen (right panels) from groups of 6 mice subcutaneously immunized with the corresponding vaccine and after a 4 weeks intranasal challenge against (a) H37Rv (lineage 4 strain), (b) W4-Bejiing (lineage 2 strain) and (c) HCU3524 (lineage 3 strain). All data are mean ± SEM. Asterisks indicate * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001 [One-way ANOVA, Bonferroni post-test].