Figure 5.

Isolated Activity Profiles of Significant Clusters of Malignant Cells in the Venteicher et al. Astrocytoma Dataset

Top: distinct significant clusters are identified by alternating black and gray color bars. Cells are ordered left to right according to the overall cluster data including all cells, although only significant clusters of five cells or more are displayed. Middle: Heatmap of PCA-based activity scores. All principal components were used for clustering analyses, but only those explaining >3% of total variance are displayed. PCA scores are ordered top to bottom according to complete hierarchical clustering based on Euclidean distances. Bottom: Heatmap of normalized activity scores, ordered top to bottom according to complete hierarchical clustering based on Euclidean distances.