Figure 7.

Differences and Dynamics of Phenotypic Diversity

(A) Distribution of phenotypic divergence between malignant cells in each sample across six datasets. Samples ordered by sample-wise phenotypic diversity (average divergence). ∗∗∗: p < 0.001; ∗: p < 0.05 (Wilcoxon test, BH correction). Boxes represent the middle quartiles; black horizontal bars represent the median of each distribution; whiskers extend up to 1.5 times the interquartile range (box height) away from the box. Outliers (beyond the whiskers) are not displayed.

(B) Per-sample phenotypic diversity in all six sets.

(C) Coefficient of variation in phenotypic diversity across samples in each set.

(D) Phenotypic divergence distributions in normal and cancerous epithelia in five patients from the Li et al. dataset. Dashed horizontal line: total average; broad horizontal lines: individual distribution averages.