Table 1.

Summary of VDJ sequencing results for patients 1 to 6

Patient	Disease event	Dominant VDJ rearrangement	No. of unique VDJ rearrangements	Dominant rearrangement (% of total reads)	No. of unique subclones with dominant VDJ rearrangement
1	Diagnosis	V3-30, D3-16, J6	29	99.03	1690
	Transformation	V3-30, D3-16, J6	313	94.95	2727
2	First relapse	V3-11, D3-16, J1	105	95.04	3530
	Third relapse	V3-11, D3-16, J1	12	99.33	3032
	Transformation	V3-11, D3-16, J1	129	99.23	3966
3	Second relapse	V3-48, D1-26, J4	164	88.23	4103
	Third relapse	V3-48, D1-26, J4	261	71.10	2057
	Transformation	V3-48, D1-26, J4	143	84.81	1592
4	First relapse	V3-48, D3-10, J6	101	56.60	81
	Second relapse	V3-48, D3-10, J6	324	69.70	248
5	First relapse	V3-23, D4-23, J6	224	53.30	140
	Third relapse	V3-23, D3-3*, J5*	433	70.70	371
6	FL diagnosis	V3-23, D5-18, J6	7,931	82.40	2510
	tFL diagnosis	V3-23, D5-18, J6	2,436	89.60	3442
	tFL relapse	V3-23, D5-18, J6	1,204	93.10	4749

^*Although samples of patient 5 have different DJ rearrangements according to IMGT, when aligned they show highly similar CDR3 regions and share a t(14:18) breakpoint, indicating a clonal relationship.

For patients 4 and 5, information in table was obtained from Carlotti et al,¹⁶ and patient 6 information was obtained from Jiang et al.¹⁷