Fig. 1.

Gene set enrichment plot of genes regulated by BPA. GSE26728 includes microarray data of CD-1 mice at 9 weeks of age treated with low and high doses of BPA (50 μg/kg/day and 5,000 μg/kg/day, respectively) for 28 days in their feed. The results of GSEA of DEGs between negative control and BPA treatment groups were visualized using the JavaGSEA package. The most significantly enriched signaling pathways were selected based on the normalized enrichment score (NES), with a nominal P-value < 0.05, and false discovery rate q-value < 0.25. The y axis represents the enrichment score, and the x axis lists genes that showed high levels of expression induced by BPA treatment among the 22,514 total genes. The black bar indicates the locations of the genes in each gene set. BPA, bisphenol A; DEGs, differentially expressed genes.