Fig. 3.

Differential gene expression induced by BPA treatment with or without KRG in mouse liver and uterus. The levels of mRNA transcripts in mouse liver and uterus were determined by the library preparation and sequencing method. Venn diagrams show the classification of DEGs in the BPA group and BPA plus KRG group in the mouse liver (A) and uterus (B). Numbers represent the numbers of genes showing a more than twofold change in expression compared with negative controls. Upper numbers, upregulated genes; lower numbers, downregulated genes; middle numbers, contraregulated genes. Under the same conditions, genes with different expression levels between the BPA plus KRG group and the BPA-only group in the mouse liver (C) and uterus (D) were selected and charted by the percentage of genes in each gene ontology out of the total number of genes. The numbers of genes upregulated or downregulated in the liver (E) and uterus (F) in the BPA plus KRG group are shown in red and green bar graphs, respectively. BPA, bisphenol A; KRG, Korean Red Ginseng; DEGs, differentially expressed genes.