Fig. 4.

Analysis of wrinkle-related gene expression in UVB-irradiated skin. After 5 weeks, the skin tissues were isolated from HRM-2 mice and MMP-2, MMP-9, and IL-1β gene expression was analyzed. (A) MMP-2 production was significantly reduced by KRG, as determined by ELISA. (B) MMP-2 mRNA expressions was significantly decreased in both KRG-treated groups, as determined by qRT-PCR. (C) MMP-9 mRNA expressions was significantly decreased by KRG, as determined by qRT-PCR. (D) IL-1β expression was significantly decreased by KRG, as determined by qRT-PCR (K= KRG). The values in bar graphs are the mean ± SEM from three independent experiments. ***p < 0.001 and **p < 0.05 compared with the control UVB irradiated mice.

KRG, Korean Red Ginseng; MMP, matrix metalloproteinase; IL, interleukin; ELISA, enzyme-linked immunosorbent assay.