TABLE 2.

Univariate and multivariable binary logistic regression for preoperative factors associated with incomplete cytoreduction within the derivation cohort (n = 998)

Variable	Univariable			Multivariate
	OR	95% CI	p Value	OR	95% CI	p Value
Male	2.2	1.4–3.2	< 0.001	3.4	1.4–8.6	0.007
Age (continuous, per year)	1.1	1.0–1.1	0.015	0.6	0.2–2.3	0.473
Histology
Noninvasive appendiceal	Ref	–	–	Ref	–	–
Invasive appendiceal	1.7	1.1–2.7	0.035	1.1	0.4–2.9	0.881
Colorectal	0.7	0.4–1.4	0.364	1.8	0.4–8.6	0.473
Peritoneal mesothelioma	2.4	1.2–4.9	0.014	2.4	0.6–9.8	0.240
Prior cardiac event	2.2	1.1–4.7	0.032
Ascites	2.0	1.2–3.2	0.006	2.8	1.1–7.2	0.028
Previous abdominal surgery	0.4	0.2–0.8	0.004
Previous cytoreduction	1.7	1.1–2.5	0.014	2.4	0.8–6.8	0.109
CA-125 ≥ 40 U/mL	3.3	1.6–6.7	0.001	3.3	1.3–8.8	0.012
CA 19–9 ≥ 125 U/mL	2.3	1.1–5.1	0.032	0.9	0.3–2.7	0.858
CEA ≥ 4.2 ng/mL	2.4	1.3–4.1	0.003	3.2	1.1–9.1	0.029
Albumin ≥ 3.85 g/dL	0.3	0.2–0.5	< 0.001	2.2	0.9–5.5	0.085

Preoperative factors not associated with incomplete cytoreduction were race, BMI, functional status, long-term anticoagulation, congestive heart failure, dyspnea, diabetes mellitus, liver disease, genetic syndrome, alcohol use, smoking use, preoperative imaging PCI, presence of symptoms, and previous HIPEC. Previous abdominal surgery and prior cardiac event were excluded from multivariable analysis due to the small number of patients with this variable available