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Scheme of possible mechanisms of SiO2-NPs recognition by THP-1. (1) SiO2-NPs-Pro: nanoparticles be deposited of activated complement proteins; (2) SiO2-NPs: nanoparticles which were not incubated with human serum and were without adhesive protein on the surface; (3) SiO2-C: activated complement supernatant after incubation and centrifuge of nanoparticles and human serum (∗P < 0.05 versus NC group).
