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. Author manuscript; available in PMC: 2020 May 2.
Published in final edited form as: Pancreatology. 2019 Nov 21;20(1):101–109. doi: 10.1016/j.pan.2019.11.011

Figure 1. Alterations in tumor desmoplasia following combined Vismodegib and Erlotinib treatment.

Figure 1.

A, H&E staining of tumors from two patients with undifferentiated pancreatic adenocarcinomas demonstrates changes in the stromal reaction following treatment. There was a decrease in the amount of collagen deposition in the tumor from patient 3 and a decrease in the overall percentage of desmoplasia in the tumor from patient 4. B, Quantitative RT-PCR of COL1A1 gene expression from paired patient samples. The H&E stained sample from patient 4 in A correlates with patient 4 in B. C, Pathology review of H&E of biopsies from paired patient samples characterizing extent of desmoplasia.