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Cohort I dose escalation (all cycles)
| Dose levels | Erlotinib (mg/day)* | Vismodegib (mg/day) |
|---|---|---|
| −1 | 25 | 150 |
| 1 | 50 | 150 |
| 2 | 75 | 150 |
| 3 | 100 | 150 |
| 4** | 150 | 150 |
As assigned by the Registration Office upon enrollment
Dose level used in cohort III
Cycle length = 28 days; for all cycles, Erlotinib and Vismodegib taken orally on days 1-28.
Erlotinib and Vismodegib taken on an empty stomach (1 hour prior to or 2 hours after eating)
