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Cohort II dose escalation (all cycles)
| Dose level | Erlotinib (mg/day)* | Vismodegib (mg/day) | Gemcitabine (mg/m2/day)* |
|---|---|---|---|
| −2 | 75 | 150 | 600 |
| −1 | 75 | 150 | 750 |
| 1 | 75 | 150 | 1000 |
| 2 | 100 | 150 | 750 |
| 3 | 100 | 150 | 1000 |
As assigned by the Registration office upon enrollment
Cycle 1 length = 28 days
Erlotinib and Vismodegib taken orally daily throughout each cycle; gemcitabine administered on days 1, 8 and 15, followed by 1 week of rest
