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Factors contributing to resistance to CDK4/6 inhibitors.
| Resistance type | Resistance mechanism |
|---|---|
| Cyclin-CDK complex increase | CDK6 amplification |
| CCNE1 amplification | |
| Cyclin D-CDK4/6-Rb pathway regulation |
Cyclin D deficiency Rb inactivation or deletion |
| FAT1 loss | |
| Others | FGFR1 amplification |
